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The purpose of the present study was to assess whether or not cadmium(II) and lead(II) affect the mobilization of exogenously provided copper(II) and zinc(II) in liver cells by interfering with cellular uptake and/or efflux systems. The incubation of isolated rat hepatocytes with lead(II) or cadmium(II) alone showed no significant effects on cellular copper(II) and zinc(II) uptake. However, the incubation of hepatocytes with 10 microM cadmium(II) or 10 microM lead(II) together with 10 microM copper(II) or zinc(II) prevented both cellular copper(II) and zinc(II) accumulation. Cellular efflux was not influenced by lead(II) or cadmium(II) at concentrations of 10 microM or 5 microM, respectively. Only 1 microM copper(II) caused a marked stimulation of zinc(II) efflux from isolated rat hepatocytes. Taken together, these results suggest that cadmium(II) and lead(II) interfere with copper(II) and zinc(II) cellular influx, whereas they What's New In Adobe Photoshop 2021 (Version 22.5)? 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